Signed in 1964 on its current alignment

In 1932, the road was paved from Selinsgrove to Kratzerville and from Little Mexico Road to New Berlin.  In 1935, the section in Kratzerville was paved.

In 1950, the section from PA 158 to New Castle Road was paved.  In 1959, the western terminus was move to its current location from PA 158 via Leesburg Station Road.  Also the eastern terminus was moved from PA 38 west of Emlenton to Shippensville.

In 1968, the eastern terminus was moved to its current location.

In 1940, the section from Girty to Oak Hill Road was paved.  In 1947, the section in Girty was paved.

In 1966, construction started on a new alignment between Gastown and Sagamore due to the creation of the Plum Creek Reservoir.  This section opened in 1967.

Construction began in Spring 2008 on the Loganville Connector, which cuts through the northern parts of the borough while removing traffic from passing through its center via West Ore Street and North Main Street, and thus creating a shorter route to Interstate 83.  The new $6.7 million alignment opened on October 5, 2009.

In 1930, the northern terminus was moved from West Pittston to Hughestown.  In 1935, the section from the Jenkins Township line to Dupont to was paved and in 1938, the section from Gouldsboro to Bear Creek Village was paved.

Signed in current location in 1962.  In 1969, southern terminus moved from Albion via Albion Road to its current location.

The eastern terminus moved from Susquehanna Trail onto Church Street from Glen Rock to to I-83 in 1960 then moved to its current location in 1961.  The route was moved back to the original alignment from Glen Rock to Susquehanna Trail in 1971.

Signed in 1961.

Signed in 1936 on its current alignment.

In 1940, a section from Oak Ridge Road to just south of Acheson was paved.  Paving continued in 1946 at Pleasant Valley Road.  Also, until 1946, another section was signed as PA 221 from PA 121 between Newtown and Poland Mines on Dunkard Hill Road.  That year that section was decommissioned.

In 1932, the route was paved from Line Mountain to Gowen City and from Burnside to Shamokin.  Also that year the route was finished from Line Mountain to Hegins.

The original northern terminus was PA 25 and PA 125 in Hegins until 1936, that is when it was moved to Shamokin.  That year the southern terminus was moved from Berrysburg to US 22/US 322 at the intersection of Claster Boulevard and Allegheny Street in Dauphin.  It was moved yet again 1999 to end at the US 22/US 322 expressway when it opened.

Signed in 1961 on its current alignment.

In 1941, the section between the Butler County line and Slate Lick was paved.  In 1946, the western terminus was moved from Slate Lick to PA 356 in Sarver.  Also the section between Sarver and the Armstrong County line was paved.

In 1953, the section between Saxonburg Boulevard and Freeport Street was completed.

In 1970, the western terminus was moved from Sarver to its present location.  That same year, the eastern terminus was moved from Cowansville via current SR 3011 to PA 28 at Exit 18.

Until 1984, the eastern terminus was PA 28 at Exit 18.  The route continued past PA 356 on current SR 2018 in Butler County and SR 3004 and SR 3017.  That year it was moved to its current location.

In September 2002, with the explosion of growth in the Cranberry area, alternative routes were explored.  One involved widening PA 228, while two others proposed new alignments of PA 228:  one north of the existing route, and one south.  The northernmost route would run through Middlesex, Adams, Seven Fields, and Cranberry and the southernmost route would run through Middlesex, Valencia, Pine, Marshall, and Cranberry.  These were reject for reasons ranging from environmental impact to socio-economical impacts.  Seven alternative exist for PennDOT to consider, with construction to begin in 2008.  With PennDOT restructuring their 12-Year Transportation Program, this study is being reevaluated.

Officials in Buffalo Township feel slighted by all the attention being given to the western end.  Widening PA 356 has been discussed, but using PA 228 to siphon traffic off of it would be a better plan.  The needed improvements are because the township is growing with people and industry.  PennDOT says that any improvement to the eastern end will come after the western end is improved.

A median was installed in 1977 at Harrisburg International Airport to facilitate traffic to and from the new Airport Connector.  In 1979, the route was multiplexed with US 22 and its western terminus was moved to I-81 at Exit 67.  In 1987, the western terminus was moved back to its current location.

In 1941, the section from the Cumberland County line to Laurel Run Road was paved, and the sharp curve near the county line eliminated.  Also that year, the northern terminus was moved from PA 17 in Icklesburg to its current location.

In 1940, the section from the Juniata County line to Lick Run was improved.  In 1941, the section from Lick Run to Three Rivers Road was paved. The northern terminus was moved to its current location from US 522 in Beaver Springs in 1946.  The route was paved between PA 35 and Lick Run in 1947.

In 1971, the designation was moved to its current routing to bypass Beaver Springs.  Prior to that year, it traversed the borough on Spruce Street, Center Street, and Pine Street.

Signed on its current alignment in 1961.

In 1936, the southern terminus was moved from US 11 in Shickshinny, to PA 29 in Koonsville.

In 1966, the northern terminus was moved to its current location from PA 254 in Benton and the southern terminus was moved to its current location from US 11 in Shickshinny.

In 1961, the southern terminus was moved from PA 743 in Maytown to its current location

In 1964, the eastern terminus was moved from PA 44 south of Bloomsburg to Newscopeck.

The southern terminus moved from US 6 in Blakley to PA 348 in Mount Cobb in 1946.  That year the route was moved to its current alignment from Montdale to Dundaff from Clifford Road in Lackawanna County.

In 1978, the southern terminus was moved to the current location at Interstate 84.

Signed in current location in 1966.  In 1970, the route was moved to its current route through Easton from Northampton Street to avoid the center of town.

A median was installed in 1989 from Palmer Park to US 22.

Resigned in 1961 for the York Bypass.  The highway was widened and a median installed on it from Loucks Road to North George Street in 1968.  Two years later, the same occurred between North George Street and North Hills Road.  Construction began on the route from North Hills Road to PA 24 in 1971 to upgrade it to expressway standards.  That section was completed in 1972.