In 1960, the designation was moved to the newly completed Fort Pitt Bridge to cross the Monongahela River due to the closing of the Point Bridge.  Then it turned onto a portion of Penn Avenue to Fort Pitt Boulevard and back to the original alignment.  In 1961, the southern terminus was moved to the end of the West End Bridge.

In 1982, a northern disconnected section was signed from US 19 at the northern end of the West End Bridge to Wexford.  The designation followed Western Avenue, West Ohio Street, circled Allegheny Center on the Commons, East Ohio Street, East Street, and McKnight Road.

In 1984, the alignment was changed with northbound traffic using Western Avenue, Allegheny Avenue, North Shore Drive, General Robinson Street, Anderson Street, River Avenue, and Voeghtly Street.  Southbound traffic was moved to Reedsdale Street and Beaver Avenue.  In 1989, the designation was moved onto I-279 to form a complete Truck US 19 from Mount Lebanon to Wexford after the Parkway North was completed.

Construction began in 1997 on the interchange at the southern portal of the Liberty Tunnel which was completed on November 20, 1999.