This US highway has very little history to its name. Signed in 1926, the route followed the current PA 928 alignment from the Maryland state line to Big Cove Tannery where it turned onto the current US 522 alignment. The designation shown on a Rand McNally map of Pennsylvania from 1927. US 622 was decommissioned in 1928.
Links:
Terminus of US 622 - Dale Sanderson
 INFORMATION |
| Southern Entrance: |
Maryland state line three miles south of Plum Run. |
| Northern Terminus: |
US 22 in Mount Union. |
| Length: | 55 miles |
| Names: | Tollgate Ridge Road, Big Cove Tannery Road, Great Cove Road, Second Street, Croghan Pike, Ridgley Street, Shirley Street, and North Jefferson Street |
| Counties: | Fulton and Huntingdon |
| Expressway: | None |
| Former Designation: |
PA 44 (1927 - 1928): Big Cove Tannery to Mount Union |
| Decommissioned: | 1928 |
| Replaced By: |
PA 928: Maryland state line to Big Cove Tannery US 522: Big Cove Tannery to US 22 |