In 1946, the southern terminus was moved from US 219 south of Jennerstown via the Million Dollar Highway to the current intersection with PA 985.

In 1965, the northern terminus was moved from PA 160 in Windber to its current location and in 1973 the southern terminus was moved to Somerset from US 219 just north of the town.

Work to replace the Seventh Street Bridge over Interstate 80 and McMichaels Creek in Stroudburg began on July 14, 2011.  Demolition began immediately on the eleven-span, concrete T-beam bridge that was built in 1934 and rehabilitated in 1959.  A new four-span concrete bulb T-beam bridge was built in its place.  A ribbon-cutting ceremony was held on December 18, 2012 with PennDOT Assistant District Executive for Design Alfred A. Picca, Jr., local officials, and residents in attendance.

Mother Nature was not particularly kind to the route in the early part of the 2020s.  When the remnants of Hurricane Ida blew through Northampton County on September 1, 2021, the torrential rains it brought overwhelmed and damaged a culvert on PA 611 between Raubsville Road and Browns Drive in Northampton County south of Easton.  The road was closed two days later after the damage was discovered.  The raging water damaged the road adjacent to the culvert, which carried a tributary to the Delaware River, and left a depression about 22 feet across by 11½ feet across over the culvert.  "Further investigation determined there is a hole in the side of the culvert along with undermining of the structure’s foundation," said Ron Young, Jr. of PennDOT.

The Department of Transportation needed to finalize construction plans, acquire temporary property access rights, and coordinate with the Pennsylvania Department of Conservation and Natural Resources that oversees the adjacent Delaware Canal State Park and Pennsylvania Department of Environmental Protection to secure the necessary permits in order to repair the route.  Finally, on March 4, 2022, the $600,000 repair project was complete and the road reopened, which is a far cry from the original reopening date of September 24, 2021!

Roughly a month after that section reopened, another was closed on April 7, 2022 due to damage from heavy rains which washed out a slope and retaining wall near the Northampton County/Monroe County line.  The closure encompasses the Delaware Water Gap National Recreation Area entrance north of Portland to Delaware Water Gap Borough.  The first phase of repair work began the week of April 25 and involved resetting 517 sections of concrete barrier, which crews have to remove first, shore up the base material, and then reset the section.  After that was completed, workers made repairs to the four areas that necessitated the closure.  Two were shored up with fill material, and the other two are where new concrete slabs to support the road were poured.  The route reopened to traffic on May 26, 2022.

Not erosion, but rather a rock slide caused by torrential rains closed the route on December 6, 2022 between the Northampton County/Monroe County line and Delaware Water Gap.  "Here we are again.  And it's like deja vu.  You know, so hopefully, this isn't as bad as the last time, but we don't know," said Lauren Chamberlain, owner of Asparagus Sunshine which is located right before the closure in Delaware Water Gap.  "We have a lot of events planned this weekend.  We have an artisan marketplace.  We have our Christmas marketplace at the Castle Inn.  Everyone's got stuff going on.  We have a book signing here, so yeah, it's a weekend that Saturday the town would be super busy.  It's shopping season.  So yeah, this is definitely going to put a damper on us," Chamberlain said.

On January 10, 2023, PennDOT announced that the route would be closed for at least six months in order to perform work to remove loose rock and secure the rock face.  Work will include scaling of loose rock, placing anchors into the rock, and installing wire mesh and concrete buttresses to secure the rock.  "It might not take that long, but that’s the estimate right now," said PennDOT spokesman Ron Young.  "This is pretty specialized work."  Young added that some of the fallen rock is as large as a vehicle!  Due to having to submit documents and gain approvals from the National Park Service, as PA 611 traverses the Delaware Water Gap National Recreation Area, and the Pennsylvania Department of Conservation and Natural Resources, the timetable for the work is still up in the air.

Another rock-fall took place the second week of September 2023 close to the boundary of the Borough of Delaware Water Gap and the start of the Delaware Water Gap National Recreation Area.  "This area remains a safety concern until work begins as another secondary rock-fall event occurred following rainfall earlier this week," said Sean Brown, press safety officer for PennDOT Engineering District 5.  “The proposed scaling operations will remove the potential hazards surrounding the rock-fall locations and other immediate hazards throughout the corridor."  This happened amid pleas from the borough to get the road open.  "Our borough along with other boroughs are trying to put pressure on PennDOT and the National Park Service (NPS) to complete the work needed to re-open 611," Delaware Water Gap Mayor Larry Freshcorn said.  On September 14, the National Park Service said it had finished its review of PennDOT’s Special Use Permit application and supporting documents, compiled questions and comments regarding them, and planned to return them to PennDOT by close of business.  "This project has been and remains a top priority for the NPS and we understand the impact the road closure has had on residents and local communities and continue to work with PennDOT to meet our mutual goals of safe travel on Route 611 and the protection of nationally, locally, and tribally significant resources,” said Kathleen Sandt, Delaware Water Gap National Recreational Area spokesperson.

In 1966, the southern terminus was moved from the Maryland state line in New Freedom to its current location in Railroad.

Signed in 1961 on its current alignment.

From 1928 to 1952, the route was signed from Hughesville to PA 239 in Lycoming County. Paved from Hugesville to Green Valley Road in 1930.  Paved from Green Valley Road to Lairdsville in 1932.  Paved in 1939 from Lairdsville to Holmes Hollow Road.  Paved from Holmes Hollow Road to Biggertown in 1946.

Signed in 1952 in its current location.

Signed in 1964 in its current location.