|Southern Terminus:||US 422 at North Chew Avenue in Philadelphia|
|Northern Terminus:||US 611 in Willow Grove|
|Names:||East Mount Airy Avenue, Wadsworth Avenue, and Easton Road|
|LR Designation:||67354: US 422 to the Montgomery County line|
|County:||Philadelphia and Montgomery|
|History:||Signed in 1948.|
|Southern Terminus:||US 611 in Portland|
|Northern Terminus:||US 611 in Tannersville|
|Names:||State Street, Delaware Avenue, North Delaware Drive, Main Street, Foxtown Hill Road, Park Avenue, South 7th Street, North 9th Street, and Lackawanna Trail|
|LR Designations:||166: Portland to Broad Street in Delaware Water Gap and 7th Street to 9th Street in Stroudsburg
498: Broad Street to PA 191 in Stroudsburg
49806: PA 191 to Main Street in Stroudsburg
168: Main Street to Tannersville
|Counties:||Northampton and Monroe|
|Multiplexed Route:||Business US 209: South 7th Street to North 9th Street in Stroudsburg|
||PA 2 (1925 - 1928): Portland to Broad Street in Delaware Water Gap and South 7th Street in Stroudsburg to Tannersville
PA 32 (1927 - 1928): Broad Street in Delaware Water Gap to Stroudsburg
PA 302 (1928 - 1930): Bangor Mountain Road to Main Street in Stroudsburg
PA 612 (1928 - 1933): Broad Street in Delaware Water Gap to Bangor Mountain Road
US 611 (1928 - 1954): Portland to Broad Street in Delaware Water Gap
US 611 (1928 - 1963): Stroudsburg to Tannersville
US 611 (1933 - 1954): Broad Street in Delaware Water Gap to Foxtown Hill Road
US 611 (1933 - 1963): Main Street in Delaware Water Gap to Main Street in Stroudsburg
|Replaced By:||US 611|
Signed in 1954 on the original US 611 alignment between Portland and Delaware Water Gap. The reason for the creation of the route was due to construction of the Portland-Columbia Toll Bridge and Delaware Water Gap Toll Bridge, both of which opened in December 1953 by the Delaware River Joint Toll Bridge Commission. New Jersey desired to connect both with a four-lane, divided highway which eventually would become part of Interstate 80, unlike the route between the two Pennsylvania boroughs which did not lend itself to extensive improvements due to topography. Alternate US 611 would act as the "free route," while US 611 would become the "toll route." The American Association of State Highway Officials' US Route Numbering Committee approved the shift of US 611 into New Jersey and the creation of Alternate US 611 at their December 8, 1952 meeting in Kansas City, Missouri, with the Executive Committee following suit with their approval at their meeting the following day.
Also in 1954, the route was widened between Slateford and Delaware Water Gap.
The first change in its northern terminus took place in 1960 when the route was extended northward via Foxtown Hill Road, Park Avenue, and South 7th Street to end at US 611 in Stroudsburg. A year later, the southern terminus would be changed from the interchange at the southern end of the Portland-Columbia Toll Bridge to US 611 via that route's original alignment on State Street.
The second and final change to the northern terminus took place in 1963 when it was moved from US 611 in Stroudsburg to US 611 in Tannersville. The route was extended over US 611's former alignment as that route had been moved onto the recently completed Interstate 80, which it followed from New Jersey to the Tannersville interchange.
Alternate US 611's fate would be sealed on September 23, 1964 when the State Highway Department of New Jersey petitioned the American Association of State Highway Officials to delete US 611 in the Garden State and have it moved back to the western shore of the Delaware River between Portland and Delaware Water Gap. The Pennsylvania Department of Highways followed suit with their paperwork on October 14, just six days shy of the October 20 deadline to make the agenda for AASHO's meetings on December 5 and 6. They gave three reasons for the change: elimination of the needless Interstate 80/US 611 multiplex, provide a traffic route for the highly commercialized Pocono resort area, and to avoid directing traffic over toll bridges at Portland and Delaware Water Gap. Many motorists objected to having to pay tolls to follow US 611 when a shorter, toll-free route was available. The US Route Numbering Subcommittee approved the applications on December 5, and the AASHO Executive Committee doing the same a day later.